OPTIMIZATION OF PHARMACOTHERAPY BASED ON RESEARCH OF DRUG BIOTRANSFORMATION
DOI:
https://doi.org/10.30888/2709-2267.2024-23-00-035Keywords:
biotransformation system, medicinesAbstract
studies show that one of the main causes of interindividual and intraindividual variations in the concentration of drugs when taken in standard doses is the change in the rate of biotransformation of drugs and the activity of transporters.Metrics
References
Kukes V.G., Ramenskaya G.V., Kuchumov R.S., Sychev D.A. and others. The significance of genotyping of polymorphic “slow” alleles of cytochrome P-450 2D6 for an individualized assessment of the pharmacokinetics of amitriptyline in the Moscow population. //Clinical trials of drugs in Russia.-2002.-No. 3-4. -p.40-46.
Kukes V.G., Ramenskaya G.V., Sychev D.A., Ignatiev I.V. New clinical and pharmacological approaches to improve the effectiveness and safety of pharmacotherapy. Materials of the Russian Medical Forum “Fundamental Science and Practice”. - 2006.- p. 80.
Kukes V.G., Sychev D.A. Clinical pharmacology of non-narcotic analgesics. //Clinical pharmacology and therapy. -2002. -t.11. - No. 5. -p.73-78.
Kukes V.G., Sychev D.A. and others. I/D polymorphism of the angiotensin-converting enzyme gene: pharmacogenetic aspects. Far Eastern Medical Journal. -2006. -No. 2. -With. 107-110. 10
Kukes V.G., Sychev D.A. et al. The effect of verapamil on the activity of glycoprotein-P, assessed by the pharmacokinetics of fexofenadine: clinical observation. //XI Russian National Congress "Man and Medicine". Conference materials. -2004. -p.212.
Kukes V.G., Sychev D.A. (and others. Clinical pharmacogenetics and practical healthcare: prospects for integration. // Proceedings of the conference “Clinical and pharmacological approaches to optimization of pharmacotherapy” - 2006. - p. 3.
Kolesnikov S.I., Glazyrin A.L. Kolesnikova L.I. Distribution of enzymes that catalyze reactions with oxidized glutathione in the human placenta (marker-histochemical studies). Bulletin CO PAMN.- 1993.- N4.- C 23-26.
Kolesnikov S.I., Kaznacheev V.P. Kulikov V.Yu. Kolesnikova L.I. Kolesnikova O.P. Reactions of free radical oxidation of lipids during physiological and complicated pregnancy in the clinic and experiment. Obstetrics and Gynecology - 1979, No. 4.
Kolesnikov S.I., Rakhmanov I.N. Semenyuk A.V. Slynko P.T. Sviridov A.V. Quantitative determination of antipyrine and its metabolites in urine using microcolumn HPLC. Chemical-pharmaceutical journal - N 3. - 1989
Kolesnikov S.I., Semenyuk A.V. Ivanov V.V. Salganik R.I. Changes in the metabolic processes of an adult organism under the influence of chemical compounds during embryonic development. Bulletin CORAMN No. 1, 1991, Novosibirsk
Kolesnikov S.I., Semenyuk A.V. Kolesnikova L.I. and others. Induction of microsomal monooxygenases and assessment of lipid peroxidation in the human liver In the book: Proc. 2 All conf. "Cytochrome P-450 and environmental protection", M, 1985
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