Have been considered the role of hemic hypoxia, which arose against the background of nitrite-induced dementia of the Alzheimer type in rats on the dynamics in biochemical indicators of energy metabolism, the degree of hypoxia, the content of acetylcholine in the brain tissue homogenate in comparison to the control, where it was found: a decrease in the synthesis and transport of acetylcholine, the intensity of energy exchange, an integral indicator of the decrease in the level of which is the ATP content. The level of cholinodeficiency, hypoxia, and tissue energy supply (ATP) was almost the same between the Nitr-14 and Nitr-28 groups, but the level of cardiolipin in brain homogenates decreased proportionally with increasing duration of sodium nitrite administration.